Van de Ven Brace Ends Everton's Unbeaten Streak at New Stadium
The Dutch defender emerged as the initial defender to score twice in a Premier League game for Tottenham since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads into the net two times in first half
The home side's Jake O'Brien has goal ruled after video check
Senegalese midfielder scores third in dying moments
The defeat is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs prolonged their unbeaten run on the road in the top division and delivered Everton their first defeat at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their new ground at Bramley-Moore Dock, having departed their historic home behind after 133 years at the conclusion of last season.
But Spurs captain Van de Ven struck twice from corners in the opening 45 minutes to place their strong form at risk, and they were failed to mount a comeback before the midfielder - set up by former Toffees attacker the Brazilian - nodded in a third to put the game to bed.
Jake O'Brien believed he had levelled the tally a short while after the defender's first goal, glancing a bullet header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a handful of chances, while the Italian goalkeeper made a succession of excellent saves to ensure the London club went five away games without defeat in the Premier League.
But the video assistant referee intervened, instructing the match official to check the goal on the pitchside monitor and the referee decided that Jack Grealish and the attacker were in offside positions and had impeded with the Tottenham goalkeeper.
The win elevates Thomas Frank's team into third place in the Premier League, a handful of points off local foes and leaders Arsenal.
The Merseyside club remain in 14th position and sit six points clear of the drop zone.
Tottenham analysis: Van de Ven excels in role at both ends of the field
Following a uninspiring weekday performance in the Champions League against Monaco, where they managed a only two shots on target, Frank chose the French striker in attack instead of ex-Everton forward the Brazilian.
The new arrival was failed to influence the game before being substituted for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the end.
Centre-back the Dutchman converted into an offensive threat to be feared.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball toward the six-yard box for an unmarked the defender to score.
And Ven de Ven - stepping up as skipper in the Argentine's absence - added his second in added time as he rose above the England keeper to nod in.
Van de Ven was equally impressive in defence, partnering effectively with Kevin Danso as the duo dealt excellently with the numerous deliveries sent their way by the opposition.
Everton analysis: Everton missing finishing touch
The club's new home had been a happy hunting ground, but it seems the novelty may have worn off somewhat and fans headed to the gates after Sarr's final goal for Spurs.
The break in the team's unbeaten home run won't be a major concern for the manager, but their striker situation are.
Beto and the other striker - the Toffees' two recognised centre-forwards - had scored only one league goal between them before the weekend's match.
And they were failed to contribute to that poor tally on a damp and dreary night on in Liverpool.
The striker's form was epitomized when he chose to overhead kick a clear chance from near the goal, despite having space and time to readjust for a more conventional shot that would have challenged the keeper.
Barry, as well, was unable to make an impact after replacing the starter in the 65th minute.
It wasn't for a lack of chance. The majority of the home side's offensive moves came through the winger and the forward, who tirelessly whipped threatening balls into the Spurs box.
Upcoming fixtures for these two sides?
The Toffees: The team travel to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Spurs: The London club go to St James' Park on late October for their next round Carabao Cup tie against the Magpies.